![]() Compare plasma paracetamol levels with treatment graph (figure 1). Oral or intravenous antidote for paracetamol overdose Free Simon Clarke, Specialist Registrar, Katrina Herren, Research Fellow .uk Abstract A short cut review was carried out to establish whether there was any evidence to decide between oral or intravenous antidote in paracetamol (acetaminophen) poisoning. This safe antidote may be helpful in severely poisoned patients. Plasma paracetamol 4 hours after ingestion (but not before). This safe antidote may be helpful in severely poisoned patients.ĪB - Growing clinical and basic science data support the use of fomepizole as an adjunct to N-acetylcysteine in paracetamol poisoning. N2 - Growing clinical and basic science data support the use of fomepizole as an adjunct to N-acetylcysteine in paracetamol poisoning. The only clinically approved antidote is N-acetylcysteine (NAC), which promotes the recovery of hepatic GSH. If not treated immediately: Large overdoses can lead to serious liver damage, although you. Liver injury and acute liver failure caused by acetaminophen (APAP, N-acetyl-p-aminophenol, paracetamol) overdose is a significant clinical problem in most western countries. T1 - Fomepizole should be used more liberally in paracetamol overdose Paracetamol overdose can cause serious effects in most adults. ![]()
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